$4.5 Billion By Indy Staff Thu Sep 21, 2006 | 12:00pm Share this:Click to share on Facebook (Opens in new window)Click to share on X (Opens in new window)Click to email a link to a friend (Opens in new window)Click to print (Opens in new window)Add to Favorites $4.5 Billion The annual global wholesales for the year 2000 of Ralph Lauren, the biggest-selling designer clothing label.